The Types of Peptide Modifications and Peptide Library
Peptides are molecules of biological origin that shows various activities and have diverse functions in organisms. The incorporation of peptide modifications may have various purposes such as improving activity, tracking the peptide in the biological system under study, etc. A large variety of peptide modifications are available which are usually classified on the basis of chemical structure or chemical site of modification (Figure 1). The peptide modifications include N-terminal modification, C-terminal modification, amino acid side chain modification, amino acid -carbone modification and backbone modification. Figure 1. Peptide modifications chart. The modifications of the peptide backbone chain or of the individual amino acids have notable effects on the physical and chemical properties of the peptide overall. It may affect the hydrophobicity and thus it can enhance water-solubility. Figure 2. Peptide modificatio...